Twist Bioscience's Advanced NGS Target Enrichment Solutions
Experience the power of target enrichment in genomics research with Twist Bioscience. Cutting-edge solutions cater to a wide range of applications, including variant detection, genome-wide or exome studies, and disease diagnosis.
Join us in writing the NGS future together, shaping a tomorrow where possibilities are endless and discoveries await.
About Twist Bioscience
Twist Bioscience, located in San Francisco, USA, have pioneered a revolutionary approach combining precise oligonucleotide synthesis and a scalable silicon-based manufacturing platform.
This unique combination allows to generate high-performing probe panels for NGS target enrichment. Leveraging proprietary design algorithms and a rapid iteration pipeline, our technology enables swift design, synthesis, and optimization of custom panels. Additionally, we offer best-in-class fixed panels, such as the Twist Exome 2.0, meticulously crafted to detect rare and inherited diseases, as well as germline cancers.
Experience the future of genomics research with Twist Bioscience's NGS target enrichment solutions and unlock new possibilities for your scientific accomplishments.
Contact us today to embark on a transformative genomics journey!
Partner with Fugene Genetics
Partner with Fugene Genetics for a seamless genomics research experience. Gain access to a comprehensive suite of NGS target enrichment solutions that deliver the precision, performance, and speed required to accelerate your research breakthroughs.
Fugene Genetics proudly serves as the exclusive distributor of Twist Bioscience products in Israel. As a comprehensive solution provider, we offer a complete workflow solution for your projects. Our mission is to empower your genomics research by providing tools that customize and accelerate NGS workflows, specifically with our advanced Target Enrichment Solutions. These solutions generate focused datasets, enabling more meaningful analysis.
Learn more about NGS
Twist Bioscience NGS Target Enrichment Solutions
Fixed Panels Request Quote
Twist Bioscience provides fixed panels designed to effectively cover the target regions that matter to you. These panels are highly customizable, offering a wide range of options to suit your needs. Whether your research involves analyzing promoters, intronic SNPs, or UTRs, you can easily and cost-effectively incorporate custom content into the panel to ensure comprehensive coverage.
Exome 2.0
Twist Exome 2.0 is a powerful tool for identifying rare diseases, inherited conditions, and germline cancers. It boasts exceptional sequencing efficiency with high uniformity and a low off-target rate, reducing the need for extensive sequencing while ensuring quality data. With comprehensive coverage of major genetic databases like RefSeq, CCDS, GenCode, Clinvar, and ACMG73, Twist Exome 2.0 also includes clinically relevant non-coding pathogenic and likely pathogenic variants. This all-in-one package offers the benefits of multiple clinical panels in one customizable solution.
Mitochondrial Panel
Twist Mitochondrial Panel is a fixed content panel meticulously designed to cover the entire mitochondrial genome, encompassing 16,659 base pairs (bp) and 37 genes. This panel can be used independently or integrated as a spike-in with Twist's Human Core Exome, Comprehensive Exome, and Custom Panels. With industry-leading coverage, uniformity, and flexibility, the Twist Mitochondrial Panel empowers investigators to efficiently enrich, sequence, and analyze mtDNA variants associated with diseases, including instances of heteroplasmy.
Twist MRD Rapid 500 Panel
Gaining insights into the evolution of cancer is crucial for predicting its progression and uncovering innovative treatment approaches. While imaging and tumor biopsy testing offer valuable information, they are typically feasible only at advanced stages of the disease. However, minimal residual disease (MRD) testing, performed on blood samples, presents a less invasive and highly sensitive method for monitoring cancer recurrence over time. This approach opens new possibilities for early detection and ongoing surveillance of cancer with improved accuracy.
Mouse Exome panel
The mouse serves as a vital model system for exploring genetic variation, tumor mutations, phenotypic outcomes, and the therapeutic impact of pharmaceutical agents. To keep pace with evolving genetic variant databases, the Twist Mouse Exome panel is meticulously crafted using the latest information. When paired with Twist's expanding range of library preparation and enrichment reagents, researchers gain access to a comprehensive toolset that enables industry-leading coverage of target regions. This optimized approach not only enhances sequencing cost-efficiency but also maximizes sample throughput, facilitating cutting-edge research in the field.
Twist Human Methylome Panel
The Twist Human Methylome Panel focuses on 3.98M CpG sites spanning 123 Mb of genomic content, specifically targeting biologically significant methylation markers. Its extensive coverage makes it an excellent choice for investigators exploring methylation patterns in various applications, including cancer metastasis, human development, and functional genomics.
Optimized and validated for use with the Twist methylation detection system, this panel offers a complete end-to-end workflow with industry-leading performance. Its high capture efficiency enhances detection sensitivity across the epigenome, while also reducing sequencing costs. With its capabilities, the panel is well-suited for screening cohort samples and uncovering differentially methylated regions, enabling valuable insights in epigenetic research.
Custom Panels Get your own design
Twist Bioscience leverages precise oligonucleotide synthesis and a scalable silicon-based manufacturing platform to create probe panels for NGS target enrichment that deliver outstanding performance.
With Twist Custom Panels, you have the flexibility to design and build panels of various sizes, target regions, and multiplexing requirements, all while maintaining the exceptional and consistent performance characteristic of Twist NGS solutions.
Whether you choose to design a panel from scratch or enhance the content of existing panels by adding targets, you can seamlessly incorporate your Twist Custom Panel into your workflow. It works seamlessly with Twist's modular library preparation kits or integrates smoothly into an existing NGS workflow, providing you with a customizable solution tailored to your specific needs.
RNA Sequencing Request Quote
Twist's RNA sequencing workflows provide a complete NGS solution, delivering uniform libraries for RNA sequencing. Our versatile options, including targeted and whole transcriptome workflows, integrate seamlessly with our NGS reagents, even supporting challenging samples like FFPE (Formalin-Fixed Paraffin-Embedded). Choose Twist for efficient, reliable, and adaptable RNA sequencing solutions that meet your diverse research needs.
RNA Exome & Targeted Sequencing
- Exon-aware probe design for protein coding regions and unique splice sites
- Fewer reads per sample for more samples
- Targets 19708 genes and 63215 isoforms
- Greater than 1.8 fold enrichment over whole transcriptome
RNA Fusion Detection
- Enrich for known and novel fusions with the Twist Alliance CeGaT Fusion Panel
- Expert content design through collaboration with CeGaT
- Optimized complete workflow with Twist RNA Library Prep kit for sequencing ready library
- Leverage Twist core capture enrichment technology to maximize efficiency
Targeted RNA Sequencing
Create custom panels to sequence only the RNA transcripts that matter
Combine Twist RNA Library Prep, Twist Hybridization and RNA target enrichment panels
Enrich sensitivity for key targets even in low quality, degraded RNA from FFPE
Whole Transcriptome Sequencing
- Measure expression levels of mRNA, lncRNA and other RNA species
- Prepare libraries from Total RNA extracted from fresh and FFPE samples
- Combine our Twist RNA Library Prep with Twist RNA & Globin Depletion kit
- Perform RNA Library Preparation in less than 5 hours
Alliance panels Request Quote
Twist Alliance Panels, a curated collection of high-quality target enrichment panels developed in collaboration with renowned scientific institutions. These panels are designed to expedite your research across various applications, ranging from cancer diagnostics to carrier screening. If none of the available panels align precisely with your requirements, customization options allow you to incorporate spike-in coverage where needed.
Explore the Available ALLIANCE Panels:
- Twist Alliance Diversity SNP Panel
- Twist Alliance Pan-cancer Methylation Panel (1.5 MB)
- Twist Alliance Clinical Research Exome (34.9 MB)
- Twist Alliance VCGS Exome (40.1 MB)
- Twist Alliance Canine Exome (40.5 MB)
- Twist Alliance CNTG Exome (41 MB)
- Twist Alliance CNTG Rare Disease Panel (7.6 MB)
- Twist Alliance CNTG Hereditary Oncology Panel (0.2 MB)
Twist Alliance Dark Genes Panel
Enables sequencing of genes that are difficult or impossible to fully sequence with short read technology.
- Targets 389 genes (20 Mb)
- Key targets include GBA, SMN1/2
Twist Alliance Long-Read PGx Panel
Focus on important genes in pharmacogenomics that are critical to drug metabolism and patient therapeutic response.
- Targets 49 genes (2 Mb)
- Key targets include CYP2D6, HLA-A, HLA-B
Twist Human Methylome Panel Request Quote
The Twist Human Methylome Panel focuses on 3.98M CpG sites spanning 123 Mb of genomic content, specifically targeting biologically significant methylation markers. Its extensive coverage makes it an excellent choice for investigators exploring methylation patterns in various applications, including cancer metastasis, human development, and functional genomics.
Optimized and validated for use with the Twist methylation detection system, this panel offers a complete end-to-end workflow with industry-leading performance. Its high capture efficiency enhances detection sensitivity across the epigenome, while also reducing sequencing costs. With its capabilities, the panel is well-suited for screening cohort samples and uncovering differentially methylated regions, enabling valuable insights in epigenetic research.
Long reads panels Request Quote
Leverage the power of Twist target enrichment and long read sequencing to achieve efficient and scalable sequencing of crucial genomic regions. The utilization of Twist Alliance panels provides researchers with cost-effective and high throughput capture of target regions. Furthermore, customers have the flexibility to develop fully customizable and scalable panels according to their specific requirements.
Tailored Panels for Long Read Sequencing
Optimized probes ensure high uniformity and sequencing efficiency
Achieve balanced coverage even in challenging-to-sequence or difficult-to-map regions
Design custom panels to facilitate cost-effective and flexible scaling
Scaling Long Read Sequencing
Employ a protocol specifically optimized for enriching long fragments
Maximize sample throughput within a single sequencing run
Enable the study of targeted regions across large cohorts
Accurate Variant Calling with Targeted HiFi Sequencing from PacBio
Achieve high accuracy variant calling for SNPs, SVs, and indels
Benefit from unambiguous haplotype resolution and long-range phasing
Compatible with Sequel IIe and Revio Systems, ensuring seamless integration
Library preparations Request Quote
Twist Library Preparation Kits revolutionize the construction of high-quality DNA libraries, making them an essential tool for next-generation sequencing (NGS) applications. These kits offer two configurations, accommodating either enzymatic or mechanical DNA fragmentation, and both are meticulously optimized to facilitate library preparation for both whole genome sequencing and targeted enrichment.
The hallmark of these kits lies in their ability to consolidate library preparation steps into a single reaction, resulting in vastly improved efficiency and consistent, reliable results. By streamlining the process, researchers can save valuable time and resources while ensuring the highest quality libraries for their NGS experiments.
Whether exploring the entire genome or targeting specific regions, these kits provide the versatility and performance needed to meet the demands of modern sequencing applications:
- Versatile Fragmentation Options:
Accommodate enzymatic fragmentation for automated, high-throughput gDNA.
Utilize mechanical fragmentation for various DNA input types and qualities.
- Flexible Applications:
Compatible with both Whole Genome Sequencing and Targeted Enrichment.
Choose Twist full-length CD adapters for PCR-free library preparation.
Opt for the Twist Universal Adapter (UDI) System for maximum yield.
- Efficient Workflow:
Optimized for the Twist Targeted NGS workflow.
Process DNA samples ranging from 1 ng to 1 µg (enzymatic).
Obtain robust, amplified libraries in under 2.5 hours.
- Streamlined Library Preparation:
Combine library preparation steps into a single reaction for improved efficiency.
Ensure consistent and reliable results for your research.
The order process
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Contact us:
Reach out via phone, email (twist@fugene.co.il), or our website for product inquiries.
02
Get a quote:
Receive a detailed, customized price quote.
03
Order Confirmation & Payment:
Let us know you're ready to proceed.
04
Scheduled delivery:
We'll work with you to schedule a convenient shipment directly to your lab.
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Arrival & Check:
Inspect the products upon arrival, and we're here for ongoing support.
Sample to sequencer in a single day
From Sample to Sequencer in a Day: High-fidelity dsDNA probes, verified by NGS QC for rapid customization.
Rapid
Customization
Flexible Customization: From small panels to >1 million probes per pool, maximizing sequencing efficiency and exceptional coverage uniformity.
Maximized Sequencing Efficiency & Exceptional Coverage Uniformity
Cost-effective Sequencing: Increase coverage depth or run more samples on the same budget, ensuring no molecule is left behind.
Raise Confidence in Variant Detection
Enhanced Variant Detection Confidence: Capture every molecule, raising confidence in variant detection
